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產(chǎn)品中心抗體Polyclonal AntibodyK106494PAnti-SOCS1 Polyclonal Antibody
產(chǎn)品型號：K106494P
更新時間：2022-08-15
廠商性質(zhì)：生產(chǎn)廠家
訪 問 量 ：1076
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產(chǎn)品分類
Anti-SOCS1 Polyclonal Antibody
| 英文名稱 | Anti-SOCS1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 別名 | CIS1;CISH1;JAB;SOCS-1;SSI-1;SSI1;TIP-3;TIP3 |
| 應(yīng)用 | WB IHC |
| 稀釋比例 | WB 1:2000-5000.IHC 1:50-200. |
| 交叉反應(yīng) | Human Mouse Rat |
| 蛋白分子量 | 33kDa |
| Gene ID | 8651 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 儲存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 純化方法 | Affinity purification |
| 亞型 | IgG |
| 免疫原 | A synthetic peptide of human SOCS1 |
| 性狀 | 液體 |
| Public Immunogen Range | A synthetic peptide of human SOCS1 |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | O15524 |
| 克隆類型 | Polyclonal Antibody |
| 背景資料 | This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. |
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